MOTS-c is a peptide (a small protein fragment) encoded by mitochondrial DNA. It plays a role in regulating metabolism, particularly glucose and fat metabolism, and is thought to be involved in cellular stress responses and potentially in longevity and age-related decline. It’s been studied for its potential to improve insulin sensitivity, protect against age-related diseases, and even potentially extend lifespan.
MOTS-c is involved in regulating glucose and lipid metabolism. It can improve insulin sensitivity, which is crucial for managing type 2 diabetes.
Under stress conditions, MOTS-c translocates from the mitochondria to the nucleus, where it influences the expression of genes related to cellular protection and homeostasis.
MOTS-c is upregulated in response to exercise and is considered an exercise mimetic, meaning it mimics some of the beneficial effects of exercise on metabolism and cellular function.